Zvigadzirwa
Pyrimidine-2,4 (1H, 3h) -Dione; Cashai: 66-22-8
Synonyms: Uracil
Chemical midziyo ye pyrimidine-2,4 (1h, 3h) -dione
● Chitarisiko / Ruvara: White Poda
● Vapor Kumanikidzwa: 2.27e-08mmhg pa25 ° C
● Rolling Point:> 300 ° C (lit.)
● Refractive Index: 1.501
● Boling Point: 440.5 ° C at 760 mmhg
● PKa: 9.45 (at 25 ℃)
● Flash Pfungwa: 220.2oC
● PSA:65.72000
● Density: 1.322 G / CM3
● logp: -0.93680
● Kuchengetedza temp.:+15c to + 30c
● Solubility.
● Solub solubility .:solart mumvura inopisa
● XLOGP3: -1.1
● Hydrogen Bond anopa kuverenga: 2
● Hydrogen Bond AngelCon Kuverenga: 2
● Rinotenderera Bond Count: 0
● Chaizvoizvo Mazhinji: 112.027277375
● Anorema Atom Kuverenga: 8
● kuomarara: 161
Ruzivo rwekufa
● pikicha (s):
Xi
● Hazard Codes: Xi
● Zvirevo Zvekuchengetedza: 22-24 / 25
Zvinoshanda
Makirasi emakemikari:Biological Vamiririri -> nuclec acids uye inobva
Canonical kunyemwerera:C1 = CNC (= O) NC1 = O
Zvangoda kiriniki:Kudzidza kwe1,1% Uracil to cream cream (UTC) yekudzivirira kweruoko-tsoka syndrome
Munguva pfupi yapfuura EU miedzo:Oterzoek Naar de Farmacokinetiek Van Uracil na Orale Toedia Bij Pati? Nten akasangana neColingearu Carcinoom.
Dzazvino NiPh Criniki Miedzo: Chikamu cheIph
Inoshandisa:Yekutsvaga kwe biochemical, zvinodhaka Synthesis; Kushandiswa semishonga yemishonga, inoshandiswawo mu organic synthesis nitrowenes base pane rna nucleassides. antineopplastic mukutsvaga biochemical. Uracil (Lamivudine EP Kusvibisa F) is a nitroleyous base pane rna nucleassides.
Tsanangudzo:Uracil ndeye pyrimidine base uye chinhu chakakosha cheRNA kwasungira kune adenine kuburikidza neHydrogen zvisungo. Iyo inoshandurwa muNucleioneide Uridine kuburikidza nekuwedzera kweiyo chikepe chichibva mumufananidzo, ipapo kune iyo nucleotide uridine monophathape nekuwedzera kweboka re phosphatephate.
Tsanangudzo yeruzivo
Uraght kamera organic iri yemhuri yePrimidine inobva. Iyo heterocyclic inonhuwirira mamorekuru inosanganisira pyrimidine mhete ine maviri madhiri ekuvakidzana nitrogen maatomu. Uracil ine makemikari formula c4h4n2o2 uye inorema uremu hwe11.09 g / mol.
Uracil ndiyo imwe yemasipireya incleobases inowanikwa mune genetic zvinhu zve rna (ribonucleic acid). Inotora basa rakakosha muProtein Synthesis uye Gene kutaura. MuRNA, Uracil vaviri neAdenine kuburikidza neHydrogen Kubatanidza, kuumba maviri hydrogen zvisungo, uye ichi chigadziko chekuisa chinobatsira kuburitsa ruzivo rwechibereko.
Uracil inogona zvakare kuwanikwa mune mamwe mamwe akakosha biology mamorekuru. Semuenzaniso, chinhu chakakosha chesimba-inotakura simba inonzi ATP (Adenosine triphosphate). Uracil derivatives, senge 5-Fluororacil, yakashandiswa seAndicancer vamiririri nekuda kwekugona kwavo kukanganisa neDNA replication uye kugovera masero.
Pamusoro pekukosha kwayo kwebhaibheri, Uracil ine akasiyana emakemikari uye maindasitiri ekushandisa. Iyo inoshandiswa sechinhu chekutanga kune synthesis yemishonga yemishonga, Agrochemals, uye dhayi. Uracil derivives zvakare vanoshandiswawo mukugadzirwa kwemakwenzi uye fungicides. Uyezve, Uracil inogona kushandiswa seyakawana mumucherechedzo mukuongorora uye sechishandiso mumanyorero biology kutsvagira.
Uracil in chena crystalline yakasimba iyo isinganyanyo shoma mumvura. Iyo yakagadzikana mumamiriro ezvinhu akajairwa asi inogona kuitika kwemakemikari, senge oxidation uye kutsiva maitiro, mumamiriro ezvinhu chaiwo. Iyo compound ine pointing point of 335-338°C uye point boling of 351-357°C.
Zvakazara, Uraght muchikamu chakakosha muzvikamu zvebhaibheri zveRNA uye zvine zvikumbiro zvakakosha mune zvese zviri zviviri zvemaindasitiri uye maindasitiri emakemikari.
Application
Uracil ine mafaro akati wandei muminda dzakasiyana-siyana, kusanganisira:
Indasitiri yeMishonga:Uracil uye ayo anobva aro akashandiswa kukudziridza zvinodhaka kune zvakaringana zvinangwa. Semuenzaniso, 5-Fluorouracil inowanzoitwa chechipoterapy mushonga wekubata mamwe marudzi ekenza. Uracil-based Antivakaral mishonga, yakadai se idoxuridine uye trifluridine, inoshandiswa kurapa hutachiona hwehutachiona hwehutachiona.
Zvekurima:Uracil derivatives inoshandiswa mukugadzirwa kwemakwenzi uye fungicides. Aya makomisheni anobatsira kudzora kukura kwemasora uye kudzivirira zvirimwa kubva kune furul hutachiona.
Ongororo Chemistry:Uracil inowanzoshandiswa se chromatographic mucherechedzo kana yemukati mwero mukuongorora nzira dzechemistry. Inogona kushandiswa seyenongedzo yekuzivisa kuti uzive nguva yekuchengetwa uye kuti ive imwe mishonga mumuenzaniso.
Molecular Biology Tsvaga:Uracil inoshandiswa mumhando dzakasiyana-siyana dzezvinyorwa zvemitambo, senge polymerese ketani reaction (pcr), Inoshanda se template yeDNA synthesis kana sechinhu chekugadzira zvakananga kuzvimanikidzwa
Indasitiri yechikafu:Urails dzimwe nguva inoshandiswa seyakavharirwa seravira indasitiri yechikafu, kunyanya mukugadzirwa kwezvikafu zvakagadziriswa uye zvinwiwa.
Cosmetics:Uracil derivatives inoshandiswa mune zvigadzirwa zveCosmetic kune yavo yekunyorova uye yeganda-zvinonyaradza zvivakwa. Ivo vangabatsira kuvandudza ganda hydration uye dzivirira kubva kune zvakatipoteredza kushushikana.
Tsvagiridzo uye Kubudirira:Uracil inoshandirwawo muBiichemical uye pharmaceucucal kutsvagisa seyakagadziridza kana yepakati yekushongedza mamwe makomputa neyekuita zvinhu kana kudzidza nucle acid metabolism.
Uracric's yakakura mhando dzekushandisa dzinoratidza kukosha kwayo muminda yakadai sekurapa, kurima, kemikari, uye yebhiyoni. Vatsvaguri vanoramba vachitsvaga nzira nyowani dzekusaririra zvivakwa zvaro zvekuenderera mberi munzvimbo idzi.
