Zvigadzirwa
N, n'-diisopropylcarbodiimide; Casha Kwete: 693-13-0
Synonyms: 1,3-diisopropylcarbodiimide
Chemical midziyo ye n, n'-diisopropylcarbodiimide
● Chitarisiko / Ruvara: isina ruvara kuti isimbe yero yero
● Vapor Pressure: 34.9Pana muna 55.46 ℃
● Rolling Pfungwa: 210-212 ° C (Dec)
● Refractive Index: N20 / D 1.433 (lit.)
● Boling Point: 146.5 ° C at 760 mmhg
● Flash Pfungwa: 33.9 ° C
● PSA:24.72000
● Density: 0.83 G / CM3
● logp: 1.97710
● Kuchengetedza Temp.:26 OLOC
● Sensitive.4misture unonzwa
● Solubility.:soluble mu chloroform, methylelene chloride, acetonitrile, dioxane
● XLOGP3: 2.6
● Hydrogen Bond anopa kuverenga: 0
● Hydrogen Bond AngelCon Kuverenga: 2
● Kuverengera Bond Count: 2
● Zvakakodzera zvikuru: 126.115698455
● Anorema Atom Kuverenga: 9
● kuomarara: 101
Ruzivo rwekufa
● picotirm (s): t +,
T,
F
● Hazard Codes: t +, t, f, xn
● Zvirevo: 10-26-36 / 37 / 38-41-42 / 43-37 / 38
● Zvirevo Zvekuchengetedza: 26-36 / 37 / 37-45-38-28A - 16-22
Zvinoshanda
Makirasi emakemikari:Nitrogen Compounds -> Dzimwe Nitrogen Compounds
Canonical kunyemwerera:Cc (c) n = c = nc (c) c
Munguva pfupi yapfuura EU miedzo:Mhedzisiro yerefu yeAldara? 5% kirimu uye
TsananguroidiSopropropylcarbodiimide (dic) ndeye yakajeka mvura inogona kugoverwa nyore nyore nevhoriyamu. Izvo zvinoshanda zvishoma nezvishoma nemhepo kubva kumhepo, saka kwenguva refu yekuchengetedza bhodhoro rinofanira kuiswa nemhepo yakaoma kana inert gasi uye yakasungwa zvakasimba. Iyo inoshandiswa mune yePeptide Chemistry seyekupedzisira kudzoserwa. Iyo ine chepfu uye yakakonzeresa kusangana neDermatitis mumushandi werabhoratari.
Inoshandisa:Ichi chigadzirwa chinonyanya kushandiswa muAmIikacin, Glutatione dehddrts, pamwe neSynthesis yeAcid Andhydride, Aldehyde, Ketone, Osocynate; Kana ichishandiswa sekushomeka kwemhepo yekubvisa mumiririri, inobata kuna DicyclheyexclExELEA kuburikidza nepfupi-nguva yekuita pasi peyakajairika tembiricha. Ichi chigadzirwa chinogona zvakare kushandiswa mune synthesis yePeptide uye nucleic acid. Zviri nyore kushandisa ichi chigadzirwa kuti uite neyakaomeswa yeako carboxy uye amino-boka kuita peptide. Ichi chigadzirwa chinoshandiswa zvakanyanya mune zvekurapa, hutano, kugadzira uye zvigadzirwa zvezvisungo, uye mamwe minda yekudyidzana. N, n'-diisopropylcarbodiimide inoshandiswa seyakagadzirisazve mune synthetic organic kemikari. Inoshanda seMakemikari Intermediate uye seStabilizer yeSarin (Chemical Weapon). Iyo inoshandiswawo mune synthesis yePeptide uye nucleic acid. Kupfuurirazve, inoshandiswa sechirevo cheplostics uye inobatanidzwa mukurapwa kweiyo malignant melanoma naSarcomasi. Kuwedzera kune izvi, inoshandiswa mune synthesis yeAcid Anhydride, aldehyde, Ketone naOsocyanate.
Tsanangudzo yeruzivo
N, n'-diisopropylcarbodiimide, inowanzo kupfupikiswa se dic, ndeyemakemikari ine molecular formula c7h14n2. Iyo isina ruvara mvura inonyungudika mune yakajairika organic sols solvents seanother uye alcohols. DIC inowanzoshandiswa zvakanyanya seye organic synthesis reagent uye inotora yakakosha basa mune dzakasiyana zvemakemikari maitiro.
DIC anonyanya kushandiswa seyekuzora mumiririri muPeptide synthesis, iyo ndiyo nzira yekubatana neamino acids pamwechete kuti ugadzire mapepeti kana mapuroteni. Zvinoita seyekudzora, kufambisa kuwirirana kweAmino Acids ne Activate Carboxyl Mapoka, kazhinji kuburikidza nekuumbwa kweiyo nzvimbo isina kugadzikana inonzi ester inoshanda. Iyi yepakati inosangana neAmbino mapoka eAmino isati yasvika kumashure uye kubviswa kuti igadzire chisungo chePeptide.
Dic anoshandiswawo mune mamwe maitiro kupfuura Peptide Synthesis, akadai sekusimbisa, maAppriations, uye urethane synthesis. Zvinoita semumiriri waishayikwa mune izvi zviitiko, achifambisa kubviswa kwemamolekyudhi emvura, nekukasira kutyaira zvaunoda kumberi.
Nekuda kwekusangana kwayo uye kunhuhwirira kwakasimba, dic inofanira kubatwa nekungwarira. Izvo zvinowanzo shandiswa mune yakanyatsonaka fume hood hood uye magurovhosi anodzivirira anofanirwa kupfekwa kuti adzivirire kuonana neganda. Pamusoro pezvo, se chero kemakemikari, zvakakosha kuti utevedze maitiro akakodzera ekuchengetedza uye bvunza iyo yekuchengetedza zvinhu yekuchengetedza data (msds) yeruzivo rwakadzama.
Mukupfupikisa, n, n'-diisopropylcarbodiimiide reagent yakashandiswa mu organic synthesis yekusaita, kusanganisira Peptide Synthesis, Eptidies, emahara, uye urethane synthesis. Basa rayo seyekupedzisira mumiririri uye kushomeka mumiririri kunoita kuti chishandiso chakakosha mumunda we organic kemikari.
Application
N, n'-diisopropylcarbodiimide (dic) ine akati wandei zvikumbiro mu orghic synthesis uye mishonga yekutsvaga. Heano mamwe mashandisiro anoshandiswa e dic:
Peptide Synthesis:DIC inowanzoshandiswa semumiriri wepakati mune yakasimba-pheti yePeptide synthesis kuumba pePTIDE BOND pakati pamino acids. Inosimudzira Carboxyl mapoka eAmbino akadzivirirwa Amino Acids, achivabvumira kuti vaite neAmino mapoka, zvichikonzera kuumbwa kwezvinhu zvePeptide.
Pakati nepfungwa okusimbisa:DIC inoshandirwa semumiriri wehasha kusimudzira iyo curnensation yeCarboxylic Acids ine maAppines kana Accalhols kusagadzikana uye zvichiteerana. Iyo inofambisa kuumbwa kwemamondi uye esters nekubvisa mvura kubva mumusanganiswa wekuita.
Urethane synthesis:DIC inogona kushandiswa seyekupedzisira mumiririri mune synthesis yerethane makomputa. Iyo inogonesa kuita pakati pevasocyanates uye alcohols kuumba urrethanes.
Carbodiimiide-yakadurura coupling maitiro:DIC inowanzoshandiswa seyakajairana okutanga mune dzakasiyana siyana organic maitiro, senge synthesis yemaminda mafambiro, ePtides, uye mamwe makomendi anoshanda. Iyo inosimudzira iyo coupling ye carboxylic acids, acid chlorides, kana acyl Azides ine maAnines, hydroxylend, uye mamwe mimwe nucleophiles.
Oxidative Shanduko:DIC inogona kushandiswa mune oxidative maitiro, yakadai seiyo oxidative cleavage yeOlefins uye oxidation yeSulfices kune Sulficides kana Sulfones.
Izvo zvakakosha kuti uzive kuti dic ndeye mweya- uye unyoro-hunyoro, saka unofanirwa kubatwa munzvimbo ine tsvina kana pasi peiyo inert. Uyezve, kuchengetedza kwekuchengetedza, senge magurovhosi uye gogo, inofanira kutorwa kana ichishanda ne dic nekuda kwehunhu hwayo hune njodzi.
