N-Methyl-2-pyrrolidone

Tsanangudzo Pfupi:

Product Name:N-Methyl-2-pyrrolidone

Mashoko anoreva zvakafanana:M-PYROL(R); 1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (neKF));1-Methyl-2-pyrrolidinone(99.5%, HyDry, ine ma molecular sieves,Mvura≤50 ppm (neKF));N-Methyl-2-pyrrolidone Mugadziri;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT ( ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Product Categories:NMP;Chemical raw materials;UV/Vis);GC Headspace Solvents;GC Solvents;Solvents for GC applications;ACS and Reagent Grade Solvents;ACS Giredhi;ACS Grade Solvents;Carbon Steel Cans ine NPT Threads;Heavy Metals;Solvents for LC- ICP-MS;Toxins (kunze kwemishonga yezvipembenene/zvisaririra zvezvinodhaka);Zvikumbiro;Kuongorora kwechinwiwa;Mabhuroko ekuvaka;C4 kusvika kuC8;Chemical Synthesis;Chikafu &;GC-MS Solvents;Heterocyclic Building Blocks;ICP-OES/-MS;Pyrrolidines; Reagents for Inorganic Trace Analysis;Solvents for Metal Speciation Analysis;Solvents for Speciation Analysis (LC-ICP-MS);Spectroscopy;Trace Analysis Reagents &;Anhydrous;Zvigadzirwa;Solvent Mabhodhoro;Amines;Heterocycles;Miscellaneous Reagents;Anhydrous Solvents;Anhydrous Solvents; Kushandisa;Alternative Energy;Amber Glass Mabhodhoro;Analytical Reagents;Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV;NOLV);Materials Product Sciences Organic Solvents;Semi-Bulk Solvents;Solvent Mabhodhoro;Solvent Packaging Options;UHPLC Solvents (CHROMASOLV);NMR;Spectrophotometric Giredhi;Spectrophotometric Solvents;Spectroscopy Solvents (IR;Returnable Containers;Chokwadi/Seal Mabhodhoro;Solrovents;Biorontech; ;Chokwadi/Chisimbiso?Mabhodhoro;872-50-4;bc0001

Mol Faira:872-50-4.mol

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Pyrrolidone Chemical Properties

Melting point	-24 °C (lit.)
Boiling point	202 °C (lit.) 81-82 °C/10 mmHg (lit.)
density	1.028 g/mL pa25 °C (lit.)
mhute density	3.4 (vs mhepo)
mhute pressure	0.29 mm Hg ( 20 °C)
refractive index	n20/D 1.479
Fp	187 °F
kuchengetedza temp.	Chengetedza pa +5°C kusvika +30°C.
solubility	ethanol: miscible0.1ML/mL, yakajeka, isina ruvara (10%, v/v)
form	Liquid
pka	-0.41±0.20(Zvakafanotaurwa)
color	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
Kunhuwa	Kunhuwa kweamine zvishoma
PH Range	7.7 - 8.0
kuputika muganhu	1.3-9.5%(V)
Mvura Solubility	>=10 g/100 mL pa20 ºC
Sensitive	Hygroscopic
λmax	283nm(MeOH)(lit.)
Merck	14,6117
BRN	106420
Kugadzikana:	Yakagadzikana, asi inoora kana yasangana nechiedza.Inopisa.Isingaenderani neakasimba oxidizing agents, yakasimba acids, kuderedza vamiririri, mabhesi.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 pa25 ℃
CAS DataBase Reference	872-50-4(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyrrolidinone, 1-methyl-(872-50-4)
EPA Substance Registry System	N-Methyl-2-pyrrolidone (872-50-4)

Safety Information

Hazard Codes	T,Xi
Risk Statements	45-65-36/38-36/37/38-61-10-46
Safety Statements	41-45-53-62-26
WGK Germany	1
RTECS	UY5790000
F	3-8-10
Autoignition Temperature	518 °F
TSCA	Y
HS Code	2933199090
Dhata Yezvinhu Zvinokuvadza	872-50-4(Hazardous Substances Data)
Muchetura	LD50 nemuromo muTsuro: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg

Pyrrolidone Kushandisa uye Synthesis

Chemical Properties	N-Methyl-2-pyrrolidone imvura isina ruvara kusvika kuchiedza yero inopenya ine kakunhuhwirira kweammonia.N-Methyl-2-pyrrolidone inosanganiswa zvachose nemvura.Inonyungudika zvakanyanya mudoro rakaderera, ketones, ether, ethyl acetate, chloroform, uye benzene uye ine mwero soluble mualiphatic hydrocarbons.N-Methyl-2-pyrrolidone yakasimba hygroscopic, yakagadzikana mumakemikari, isingaparadzi yakanangana nekabhoni simbi nealuminium, uye inoodza zvishoma kumhangura.Iyo ine yakaderera kunamatira, yakasimba kemikari uye kugadzikana kwekushisa, yakakwirira polarity, uye kuderera kuderera.Ichi chigadzirwa chine muchetura zvishoma, uye chinotenderwa chinogumira mumhepo i100ppm. N-Methyl-2-pyrrolidone is solvent inoshandiswa mune zvakasiyana-siyana zvemabhizimisi uye kushandiswa, zvakadai sepende uye kubvisa kubvisa, petrochemical processing, engineering plastics coatings, makemikari ekurima, kuchenesa kwemagetsi uye kuchenesa maindasitiri / mudzimba.
Uses	N-Methyl-2-pyrrolidone (NMP) is polar aprotic solvent ine zvakanakira zvehupfu hwakadzika, nzvimbo yakakwira yekubikira, yakatanhamara solvency, yakasimba kusarudza uye kugadzikana kwakanaka.Inoshandiswa zvakanyanya mukunatswa kwekunhuhwirira kwehydrocarbon, acetylene, olefins, uye diolefins. Inoshandiswa mukuchenesa maindasitiri, uye inoshanda sechinhu chinonyungudutsa kugadzirwa kwemishonga yezvipembenene, mainjiniya mapurasitiki, machira, mafivha ekugadzira, uye maseketi akabatanidzwa. Inogona zvakare kushandiswa seyekuchenesa maindasitiri, dispersant, dhayi, lubricant uye antifreeze. N-Methyl-2-pyrrolidone inonyungudutsa yakanakisa, inoshandiswa zvakanyanya mukubvisa aromatics, mafuta ekunatsa, kuwedzera acetylene, kupatsanurwa kwebutadiene uye synthesis gasi desulfurization. Inoshandiswa mugasi desulfurization, mafuta ekunatsa, mafuta ekuzora antifreeze, olefin kudhirowa, uye seanonyungudutsa insoluble engineering mapurasitiki polymerization. Inogona kushandiswa mumishonga yesora, kuchenesa insulation zvinhu, semiconductor indasitiri kunyatsojeka zviridzwa uye edunhu mabhodhi, kudzokorodza kupera kwePVC, sedetergent, dhayi yekuwedzera uye inoparadzira mumiriri. Inoshandiswa mumasvikiro ekuita kwepolymerization senge engineering mapurasitiki uye aramid fiber. N-Methyl-2-pyrrolidone inoshandiswa se polyvinylidene fluoride solvent uye electrode axiliary material ye lithium ion mabhatiri. yakakwira kuchena giredhi rekuona ICP-MS. Nezve peptide synthesis.
toxicity	Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg.
Kurasa Waste	Bvunza mitemo yehurumende, yemunharaunda kana yenyika kuti uwane zvakakodzera.Kurasa kunofanira kuitwa maererano nemitemo yepamutemo.Mvura, kana zvichidikanwa nemishonga yekuchenesa.
storage	N-Methyl-2-pyrrolidone is hygroscopic (inotora unyoro) asi yakagadzikana pasi pemamiriro ezvinhu.Ichaita nechisimba nechisimba oxidizers akadai hydrogen peroxide, nitric acid, sulfuric asidhi, etc. The primary decomposition zvigadzirwa zvinobudisa carbon monoxide uye nitrogen oxide fumes.Kunyanya kufumurwa kana kuteura kunofanira kudziviswa senyaya yetsika yakanaka.Lyondell Chemical Company inokurudzira kupfeka magirovhosi ebutyl kana uchishandisa N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone inofanira kuchengetwa yakachena, phenolic-lined mild steel kana alloy drums.Teflon®1 neKalrez®1 dzakaratidzwa kuva dzakakodzera gasket zvinhu.Ndokumbira utarise MSDS usati wabata.
Tsanangudzo	N-Methyl-2-pyrrolidone is aprotic solvent ine zvakasiyana-siyana zvekushandisa: petrochemical processing, pamusoro pekuisa, dhayi uye pigments, maindasitiri uye edzimba ekuchenesa makomisheni, uye zvekurima uye zvemishonga.Iyo inonyanya kushatirisa, asi yakakonzerawo nyaya dzinoverengeka dzekubata dermatitis mukambani diki yemagetsi.
Chemical Properties	N-Methyl-2-pyrrolidone imvura isina ruvara kana yakareruka yeyero uye inonhuwira amine.Inogona kupinda muhuwandu hwemakemikari ekugadzirisa kunyange zvazvo inogamuchirwa sechinhu chakagadzikana chekugadzirisa.Inoshingirira kuhydrolysis pasi pemamiriro asina kwaakarerekera, asi asidhi yakasimba kana kuti base kurapwa kunoguma nekuvhurwa kweringin ku4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone inogona kuderedzwa kusvika 1-methyl pyrrolidine ine borohydride.Kurapa neklorinating agents kunoguma nekuumbwa kweamide, yepakati iyo inogona kuenderera mberi, nepo kurapwa neamyl nitrate kunoburitsa nitrate.Olefins inogona kuwedzerwa kune 3 nzvimbo nekurapa kutanga ne oxalic esters, zvino nealdehyes yakakodzera (Hort naAnderson 1982).
Uses	N-Methyl-2-pyrrolidone is polar solvent inoshandiswa muorganic chemistry uye polymer chemistry.Zvikumbiro zvakakura zvinosanganisira kudzoreredza uye kucheneswa kweacetylenes, olefins, uye diolefins, kucheneswa kwegasi, uye aromatics kutorwa kubva kune feedstocks.N-Methyl-2-pyrrolidone is a versatile industrial solvent.NMP parizvino yakatenderwa kuti ishandiswe chete mumishonga yemishonga yemhuka.Kutsunga kwemaitiro uye metabolism yeNMP mugonzo zvichabatsira mukunzwisisa toxicology yeiyi kemikari yekunze iyo munhu angangove akafumurwa pairi kuwedzera huwandu.
Uses	Solvent for high-temperature resins;petrochemical processing, mune microelectronics yekugadzira indasitiri, dhayi uye pigments, maindasitiri uye edzimba ekuchenesa makomisheni;kugadzirwa kwekurima nemishonga
Uses	N-Methyl-2-pyrrolidone, inobatsira spectrophotometry, chromatography uye ICP-MS kuonekwa.
Tsanangudzo	ChEBI: Nhengo yekirasi yepyrrolidine-2-iyo inonzi pyrrolidin-2-imwe iyo iyo hydrogen yakasungirirwa kune nitrogen inotsiviwa neboka re methyl.
Nzira dzekugadzira	N-Methyl-2-pyrrolidone inogadzirwa nekuita kwe buytrolactone ine methylamine (Hawley 1977).Mamwe maitiro anosanganisira kugadzirira nehydrogenation yemhinduro dze maleic kana succinic acids ine methylamine (Hort naAnderson 1982).Vagadziri vekemikari iyi vanosanganisira Lachat Chemical, Inc, Mequon, Wisconsin uye GAF Corporation, Covert City, California.
Synthesis Reference(s)	Tsamba dzeTetrahedron, 24, p.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
General Description	N-Methyl-2-Pyrrolidone (NMP) ine simba, aprotic solvent ine high solvency, uye yakaderera volatility.Iyi isina ruvara, yakanyanya kufashaira, yakakwirira flash point uye yakaderera mhute pressure fluid inotakura kunhuhwirira kwakapfava-kunge amine.NMP ine makemikari akakwirira uye kugadzikana kwekupisa uye inosanganiswa nemvura patembiricha yose.NMP inogona kushanda se co-solvent nemvura, doro, glycol ethers, ketones, uye anonhuwirira/chlorinated hydrocarbons.NMP inodzokororwa ne distillation uye zviri nyore kugadzirwa.NMP haiwanikwe paHazardous Air Pollutants (HAPs) rondedzero ye1990 Yakachena Air Act Amendments.
Mhepo & Mvura Reactions	Soluble mumvura.
Reactivity Profile	Iyi amine inzvimbo yakapfava yemakemikari.N-Methyl-2-pyrrolidone inowanzoita kuti acids iite munyu pamwe nemvura.Huwandu hwekupisa hunoshandurwa pa mole yeamine mukusagadzikana kunonyanya kuzvimiririra kune simba reamine sehwaro.Amines inogona kunge isingaenderani neisocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, uye acid halides.Inopisa gaseous hydrogen inogadzirwa nemaamine pamwe chete neakasimba ekudzikisa, semahydrides.
Hazard	Ganda rakasimba uye zvinogumbura maziso.Inoputika lim-yayo 2.2-12.2%.
Dambudziko rehutano	Inhalation yehutsi inopisa inogona kutsamwisa mhino nehuro.Kudya kunokonzera kushatirwa kwemuromo nemudumbu.Kubata maziso kunokonzera kushatirwa.Kudzokorora uye kwenguva refu kubata kweganda kunoburitsa nyoro, kushatirwa kwenguva pfupi.
Moto Hazard	Njodzi Dzakakosha dzeZvigadzirwa Zvinopisa: Toxic oxides yenitrogen inogona kuumbwa mumoto.
Kupisa uye Explosibility	Zvisingatsvi
Kushandiswa kwemaindasitiri	1) N-Methyl-2-pyrrolidone inoshandiswa seyakawanda dipolar aprotic solvent, yakagadzikana uye isingagadziriswi; 2) kubviswa kwemahydrocarboni anonhuhwirira kubva kumafuta ekuzora; 3) yekubvisa kabhoni dhaimoni mumajenareta eammonia; 4) se solvent yepolymerization reactions uye mapolima; 5) semucheka wepende; 6) yekugadzira mishonga yezvipembenene (USEPA 1985). Zvimwe zvisiri zvemaindasitiri zvinoshandiswa zveN-Methyl-2-pyrrolidone zvinobva pazvimiro zvayo semushonga unoparadzanisa wakakodzera electrochemical uye zvidzidzo zvemakemikari emuviri (Langan naSalman 1987).Mishonga yemishonga inoshandisa zvivakwa zveN-Methyl-2-pyrrolidone sechinhu chinonamisa kupinda kuitira kukurumidza kutamisa zvinhu kuburikidza neganda (Kydoniieus 1987; Barry naBennett 1987; Akhter naBarry 1987).N-Methyl-2-pyrrolidone yakatenderwa sechinhu chinonyungudutsa cheslimicide application kune chikafu chekurongedza zvinhu (USDA 1986).
Bata allergens	N-Methyl-2-pyrrolidone is aprotic solvent ine zvakasiyana-siyana zvekushandisa: petrochemical processing, pamusoro pekuisa, dhayi uye pigments, maindasitiri uye edzimba ekuchenesa makomisheni, uye zvekurima uye zvemishonga.Inonyanya kugumbura, asi inogona kukonzera zvakanyanya kubata dermatitis nekuda kwekugara kwenguva refu.
Safety Profile	Chepfu kubudikidza nemutsinga.Zvine muchetura zvine mwero nekupinza uye intraperitoneal nzira.Muchetura zvishoma nekubata ganda.An experimental teratogen.Experimental reproductive effects.Mutation data yakashumwa.Inobatika kana yaiswa mukupisa, murazvo wakavhurika, kana maoxidizer ane simba.Kurwisa moto, shandisa furo, CO2, kemikari yakaoma.Kana ichipisa kuti iore inoburitsa huturu hweNOx.
Carcinogenicity	Rats dzakaratidzwa kuN-Methyl-2-pyrrolidone vapor pa 0, 0.04, kana 0.4 mg / L ye6 h / zuva, 5 mazuva / vhiki yemakore 2. Makonzo echirume pa 0.4 mg / L akaratidza kuderedzwa zvishoma kurema kwemuviri.Hapana hupenyu-kupfupisa chepfu kana carcinogenic mhedzisiro yakaonekwa mumakonzo akafumurwa kwemakore 2 kusvika ku0.04 kana 0.4mg / L yeN-Methyl-2-pyrrolidone.Nenzira yedermal, boka remakonzo makumi matatu rakagamuchira dhigirii yekutanga ye25mg yeN-Methyl-2-pyrrolidone yakatevera mavhiki e2 gare gare nekushandiswa kwechirwere chekusimudzira phorbol myristate acetate, katatu pavhiki, kweanopfuura mavhiki e25.Dimethylcarbamoyl chloride uye dimethylbenzanthracene yakashanda sekutonga kwakanaka.Kunyange zvazvo boka reN-Methyl-2-pyrrolidone raiva nemapundu matatu eganda, mhinduro iyi haina kuonekwa seyakakosha kana ichienzaniswa neyekutonga kwakanaka.
Metabolic nzira	Makonzo anopihwa redhiyo-yakanyorwa kuti N-methyl-2- pyrrolidinone (NMP), uye nzira huru yekubuda nayo nemakonzo iri kuburikidza neweti.Iyo yakakura metabolite, inomiririra 70-75% yedhizi inopihwa, ndeye 4-(methylamino) butenoic acid.Ichi chigadzirwa chisina kusimba chinogona kuumbwa kubva pakubviswa kwemvura, uye boka rehydroxyl rinogona kunge riripo pane metabolite isati yasvika acid hydrolysis.
Metabolism	Murume weSprague-Dawley rats akapiwa jekiseni rimwe chete remukati (45 mg / kg) reradiolabeled 1 -methyl-2-pyrrolidone.Plasma mazinga eradioactivity uye komputa akatariswa kwemaawa matanhatu uye mhedzisiro yakaratidza kukurumidza kugovera chikamu icho chakateverwa nechikamu chinononoka chekubvisa.Huwandu hukuru hwezita hwakaburitswa muweti mukati meawa gumi nemaviri uye yakaverengera inenge 75% yeiyo yakanyorwa dose.Maawa makumi maviri nemana mushure mekunwiwa, kuwedzera kwekubuda (weti) yaive ingangoita 80% yedosi.Ese marudzi emhete- uye ane methyl-akanyorwa akashandiswa, pamwe neese [¹⁴C]- uye [3H] -yakanyorwa l-methyl-2-pyrrolidone.Mareshiyo ekutanga akanyorwa akachengetwa mukati memaawa matanhatu ekutanga mushure memushonga.Mushure memaawa matanhatu, chiropa nematumbu zvakawanikwa zviine yakanyanya kuunganidzwa yeradioactivity, ingangoita 2-4% yedosi.Little radioactivity yaionekwa mubile kana mweya wakafema.High performance liquid chromatography yeweti yakaratidza kuvapo kweimwe huru uye maviri madiki metabolites.Iyo yakakura metabolite (70-75% yeinopihwa radioactive dose) yakaongororwa neyemvura chromatography-mass spectrometry uye gasi chromatography-mass spectrometry uye yakanzi ive 3- kana 5-hydroxy-l-methyl-2-pyrrolidone (Wells. 1987).
Kuchenesa Nzira	Pukuta pyrrolidone nekubvisa mvura se *benzene azeotrope.Nefractionally distil pa10 torr kuburikidza ne100-cm column yakazara nemagirazi helices.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride ine m 86-88o (kubva kuEtOH kana Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]