Zvigadzirwa
Dl-4-chloronylglycine; Casha Kwete: 6212-33-5
Synonyms. asidhi; 4-chloripherlglycine; dl- (4-chlorinyl) glycine; (+) - 4-chlorophenecine; asidhi, .lfa-amino-4-chloro-; l-4-chloro-dl-phenylglycine; mfcd03701467; mfcd03839815; h -dl-phg (4-cl) -oh; methyln-caryeln-carbamoylmaleamate; rm2JW43tga; 2- p-chlorinyl) glycine; dl-2- (4-chloripherl ); 4-chloro-dl-2-phenylglycine; dl-2- (p-chloropherl) glycine; schemphyl #; BCP25773; BBL022163; Bbm50179705; P-Chloro-Alpha-AMinopiyAcets; Stk130690; Akos003330690; Akos00330690; Akos00590; Akos00590; Akos00590; Akos00590; Akos00590; Akos00590; Akos00330690; Akos00590; Akos00590; Akos00590; Akos00330690; acid; 7l-304s; ab012094; AB15770; AB88381; BENINE- 4 Acid; Sy017756; Sy034115; Sy034129; BB 0249643; Ft-060092; en300-408; en3002; (Tlc); q-102258; F2147-0645; Z317024646; (+/-) - 4-chloro-phenyl)-(+
Chemical chivakwa cheDL-4-chloronylglycine
● Chitarisiko / Ruvara: chena kune mwenje wellow crystal poda
● Vapor Kumanikidzwa: 7.404-05mmhg pa 25 ° C
● Rolling Pfungwa: 220-230 ° C
● Refractive Index: 1.603
● Kubirirwa Point: 328.8 ° C at 760 mmhg
● PKA: 1.81 ± 0.10 (yakafungidzira)
● Flash Pfungwa: 152.7 ° C
● PSA:63.33000
● Density: 1.392 G / CM3
● logp: 2.12470
● Kuchengetedza temp.:keep munzvimbo ine rima, inert mamiriro enzvimbo, tembiricha yemakamuri
● Solubility.:soluble mu 0.1mol / l naoh (ingangoita transpency).
● XLOGP3: -1.1
● Hydrogen Bond anopa kuverenga: 2
● Hydrogen Bond Anogamuchira Nhamba: 3
● Kuverengera Bond Count: 2
● Chaizvoizvo Mazhinji: 185.0243562
● Anorema Atomu Kuverenga: 12
● kuoma: 166
Ruzivo rwekufa
● pikicha (s):
Xn
● Hazard Codes: xn
● Zvirevo: 22-36 / 37/38
● Zvirevo Zvekuchengetedza: 26-36
Zvinoshanda
Canonical kunyemwerera:C1 = CC (= CC = C1C (C (= O) O) N) CL
Inoshandisa:Icho chinhu chakakosha chigadzirwa chakatsvuka uye chepakati chinoshandiswa mune organic synthesis, mishonga, gentomicals uye dyestuff.
Tsanangudzo yeruzivo
2-Amino-2- (4-chloryl) acetic acid inozivikanwa nezita rayo remakemikari, 4-chloro-alpha-aminobenzeneacetic acid. Iyo chena crystalline poda ne molecular formula ye c8h8clno2 uye inorema uremu hwe 185.61 g / mol.
Heano mamwe mamwezve ruzivo nezve 2-amino-2- (4-chloriphefenl) acetic acid:
Synthesis:Iyi compound inogona kuve yakanyorwa kuburikidza nenzira dzakasiyana siyana, kusanganisira maitiro e4-chlorofunone ne glycine muhusimbe yekudzora senge sodium borohydride, kana nekuita kwe4-chlorichencel bromide ne sodium glycinate.
Zvivakwa zvemuviri uye zvemakemikari:
1.muneya nzvimbo: Iyo yekunyungudika po-amino-2- (4-chlorichel) acetic acid kazhinji inotenderedza 135-140 ° C.
2.solulubility: Izvo zvinonyangadza mumvura, asi zvinopera zvakanaka mune organc sol sol solenic yakadai seEthanol naMethanol.
3.Ph: Mumvura mhinduro, iyi inomiridzo haina kusimba acidic ine ph kutenderera 5-6.
Biological Properties:
1.Kuita zvinhu zvevashoma: Kunyangwe paine ruzivo rwusina kuwanikwa pane zve pharmacological mabasa e2-amino-2- (chloricheyl) acidc acid, zvimwe zvidzidzo zvinoratidza kuti zvinogona kuve nezvinogona kuita zvehutachiona uye analgesic.
2.mometabolism: Iyo metabolic mhedzisiro yeiyi nzvimbo muvanhu haina kunyorwa zvakanaka. Nekudaro, zvinotarisirwa kuti ubate enzymatic enzymatic uye kubvisa kubva mumuviri.
Kuchengetedza Kukurukurirana:
1.Pano 2-Amino-2- ((Chlorichel) acetic Acid inoonekwa seyakaderera nechero nekuchenjerera uye kutevedzera zvakakodzera zvekuchengetedza kana kubata kana kushanda neiyi denderedzwa.
2.I zvakakosha kupfeka michina yekudzivirira, senge magurovhosi uye goggs, uye ita kuti mhepo yakakwana kana ichishanda nechinhu ichi.
3.Loways Regedza kune yekuchengetedza mashitsi (SDS) uye bvunza zvakakodzera mirayiridzo yekuchengetedza nemirairo kana ichibata uye kushandisa iyi denderedzwa.
Rangarira, ruzivo rwakapihwa pano pane general preview uye hazvifanirwe kutariswa sekureva kana kuneta. Zvekushandisa zvakanyatsoitika kana zvinangwa, zvinogara zvichikurudzirwa kubvunza zvinyorwa zvemabhuku akanyatsotarisirwa kana kuti anovimbwa nemaziso akadzikama.
Application
2-Amino-2- (4-chlorichel) acetic acid, zvakare inozivikanwa se4-chloro-alpha-aminobeneneacetic acid, ine zvingangoita maficha akasiyana siyana. Heano zvimwe zvinoshandiswa zvinoshandiswa:
Indasitiri yeMishonga:
1.Synthesis Synthesis: Inogona kushandiswa sechipfuva kana yepakati mune synthesis yemishonga yemishonga yakadai seAnaalssics, zvinodhaka-zvinodhaka, kana anti-mabhiri-mabhasiketi vamiriri.
2.Prodrug Budandukira: 2-amino-2- (4-chlorichel) acetic acid inogona kushandiswa kukudziridza prodrugs, iyo isingashande nzira dzekushandisa dzinodhaka dzinoshandurwa kune iyo inoshanda fomu mumuviri. Izvi zvinogona kubatsira kuvandudza kugona kwezvinodhaka, bioavhalability, kana kuderedza mhedzisiro.
Chemical Kutsvaga:
1.Orntic Synthesis: Iyo compound inogona kushandiswa muBaroratory yeiyo organic synthesis maitiro, kunyanya mune synthesis yeiyo yakaoma organic compac.
2.Ligand synthesis: Inogona kushandiswa kugadzirira kweiyo ligands yekubatanidza chemistry chemistry kana catalysts kune akasiyana emakemikari maitiro.
Indasitiri yeKurima:
1.Kuvhiringidzika Pestic: 2-Amino-2- (4-chloriphecenl) acetic acid inogona kuisirwa mishonga mitsva yemishonga kana mishonga inopa yakagadziridzwa kana yakaderedzwa nharaunda.
Tsvagiridzo uye Kubudirira:
1.Chemical kutsvakisisa: Iyi logpound inogona kushandiswa seyakaenzana kana chirevo chakafanana nezvinangwa zvekuongorora uye nzira yekuvandudza mumarabhoreti ekutsvagisa.
2.Kutsvagisa Biological: Inogona kushandiswa muzvidzidzo kuongorora basa reAmbines uye maReivatives avo mune akasiyana-siyana emuviri kana biochemical nzira nzira.
Ndokumbira utarise kuti zvimwe zvinoshandiswa uye zvinoshandiswa zve2-amino-2- (4-chlorichel) acetic acid inogona kutsamira pakudzedzereka nekuvandudza. Gara uchibvunza mabhuku esainzi, anodzora zvinodiwa, uye nyanzvi dzakakodzera usati washandisa kana kufunga nezvekushandisa kwayo mumunda chaiwo.
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