Di-tert-butyl dicarbonate

Tsanangudzo Pfupi:

Product Name:Di-tert-butyl dicarbonate

Mashoko anoreva zvakafanana:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, yakasimba/mvura

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Product Categories:Pharmaceutical Intermediates;Kutanga Raw Materials & Intermediates;Amino Acid Derivatives;Organics;N-Kudzivirira Reagents;Biochemistry;Peptide Synthesis;Kudzivirirwa & Derivatization Reagents (yeSynthesis); Dziviriro Reagents (Peptide Synthesis);Reagents yeOligosaganicSharidesis; Boc-Amino acid series;Miscellaneous Reagents;DIBOC;1H-Inden-1-ol;bc0001;24424-99-5

Mol Faira:24424-99-5.mol

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Product Tags

Di-tert-butyl dicarbonate Chemical Properties

Melting point	23 °C (lit.)
Boiling point	56-57 °C/0.5 mmHg (lit.)
density	0.95 g/mL pa25 °C (lit.)
mhute pressure	3.85Pa pa25 ℃
refractive index	n20/D 1.409(lit.)
Fp	99 °F
kuchengetedza temp.	2-8°C
form	Yakaderera Melting Crystalline Solid
color	Chena
Specific Gravity	0.950
Mvura Solubility	Miscible ne decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile uye dimethylformamide.Kusapindirana nemvura.
Sensitive	Hunyoro Inonzwa
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 pa25 ℃
CAS DataBase Reference	24424-99-5(CAS DataBase Reference)
EPA Substance Registry System	Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

Safety Information

Hazard Codes	T+,T,F,Xi,F+
Risk Statements	11-19-26-36/37/38-43-10-40
Safety Statements	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Germany	3
RTECS	HT0230000
F	4.4-10-21
Autoignition Temperature	460 °C
Hazard Note	Inopisa / Inogumbura / Yakanyanya Toxic
TSCA	Ehe
HazardClass	6.1
PackingGroup	I
HS Code	29209010
Muchetura	LD50 nemuromo muTsuro: > 5000 mg/kg LD50 dermal Rabbit> 2000 mg/kg

Di-tert-butyl dicarbonate Kushandisa Uye Synthesis

Chemical Properties	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) haina ruvara kusvika kuchena kune yero makristasi, yakaomeswa mikuru kana yakajeka mvura.Inonyunguduka mukati metembiricha yemumba (mp=23°C).Haina kuora panguva iyi kana kunyange kutonhora kwepamusoro zvishoma.Semuenzaniso, inowanzocheneswa ne distillation pasi pekumanikidzwa kwakaderedzwa patembiricha inosvika kunosvika 65°C.Pakupisa kwepamusoro inoora kuita isobutene, t-butyl doro uye carbon dioxide.
Uses	Di-tert-butyl dicarbonate (Boc2O) chinhu chinoshandiswa zvakanyanya kuunza mapoka ekudzivirira mu peptide synthesis.Inoita basa rinokosha mukugadzirira kwe6-acetyl-1,2,3,4-tetrahydropyridine nekuita ne 2-piperidone.Inoshanda seboka rinodzivirira rinoshandiswa mune yakasimba chikamu peptide synthesis.
Kugadzirira	Kugadzirira kweDi-tert-butyl dicarbonate kunotevera: Kune monoester sodium munyu solution yakawedzerwa 2g yeN, N-dimethylformamide, 1g yepyridine, 1g ye triethylamine, Kutonhora kusvika -5 ~ 0 ° C, 60g diphosgene yaiitwa zvishoma nezvishoma. yakawedzera dropwise mukati me1.5h dropwise kuwedzera kwainge kwapera, kuchidziirwa kusvika kukamuri tembiricha (25°C), yakanamirwa kwe2h, kuita kwakabvumidzwa kumira mushure mekusefa, kugeza organic solution.Yakaomeswa neanhydrous magnesium sulfate, iyo solvent yakabviswa pamhepo yekumanikidza kupa crude chigadzirwa 65 ~ 70g.Mushure mekutonhodzwa uye crystallization, 57-60g ye di-tert-butyl dicarbonate yakawanikwa mugoho re60-63%.
Tsanangudzo	ChEBI: Di-tert-butyl dicarbonate is acyclic carboxylic anhydride.Iyo inoshanda yakabatana ne dicarbonic acid.
Reactions	Kuita kweanotsiviwa anilines neBoc2O pamberi pehuwandu hwe stoichiometric hwe4-dimethylaminopyridine (DMAP) mune inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) pakupisa kwekamuri kunotungamirira kune aryl isocyanates mukati mehuwandu hwe10. min. Di-tert-butyl dicarbonate uye 4- (dimethylamino) pyridine yakadzokororwa zvakare.Kuita kwavo nemaamine nemadoro
General Description	Di-tert-butyl dicarbonate (Boc₂O) ndeye reagent inonyanya kushandiswa kuunza Boc kudzivirira boka kune amine functionalities.Inoshandiswawo seanobvisa mvura mumuviri mune mamwe maitiro eorganic, kunyanya necarboxylic acids, mamwe mapoka ehydroxyl, kana neprimary nitroalkanes.
Hazard	Inotsamwisa iyo inogona kukonzera kukuvara kwakanyanya kweziso;Inogona kukonzera ganda sensitization;Chakanyanya chepfu nekufemesa
Kupisa uye Explosibility	Inopisa moto
Kuchenesa Nzira	Sungunusa ester nekudziisa pa ~ 35o, uye uiise muvacuum.Kana IR neNMR ( 1810m 1765 cm-1 , muCCl4 1.50 singlet) zvichiratidza kusachena kwakanyanya, wogeza nehupamhi hwakaenzana hweH2O ine citric acid kuti aqueous layer iite acidic zvishoma, unganidza organic layer woiomesa pamusoro peanhydrous MgSO4. woidira muvacuum.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] INOPISHA.